Osteoarthritis (OA) is a chronic degenerative disease that affects millions of people worldwide, causing pain and disability. While there is currently no cure for OA, there are various treatment options available that aim to manage symptoms and improve the quality of life for those affected. One promising treatment that has gained popularity in recent years is bone marrow concentrate (BMC) therapy. In this blog post, we will explore why BMC may be a beneficial treatment option for OA.

First, let’s take a closer look at what BMC therapy entails. BMC therapy involves extracting bone marrow from the patient’s own body, typically from the hip bone. The bone marrow is then processed and concentrated to isolate the stem cells, growth factors, and other beneficial components. The concentrated mixture is then injected into the affected joint(s), where it can promote tissue regeneration and reduce inflammation.

One of the key benefits of BMC therapy is its ability to stimulate the body’s natural healing processes. Stem cells are known for their regenerative properties and can differentiate into various cell types, including those that make up cartilage and bone. By introducing these stem cells into the affected joint, they can promote the growth and repair of damaged tissue.

In addition to stem cells, BMC also contains a variety of growth factors that can aid in tissue repair and regeneration. For example, transforming growth factor-beta (TGF-beta) is known to stimulate the production of new cartilage and inhibit the breakdown of existing cartilage. Platelet-derived growth factor (PDGF) can also promote tissue regeneration and angiogenesis, which is the formation of new blood vessels that can supply nutrients to the affected area.

Several clinical studies have investigated the efficacy of BMC therapy for OA. One study published in the Journal of Stem Cell Research & Therapy found that BMC injections significantly improved pain and function in patients with knee OA at six months and one year after treatment. Another study published in the Journal of Orthopaedic Surgery and Research reported similar improvements in pain and function in patients with hip OA.

Overall, BMC therapy has shown promising results as a treatment option for OA. By harnessing the body’s natural healing processes, BMC injections can promote tissue regeneration and reduce inflammation, leading to improved pain and function in affected joints. If you are considering BMC therapy for OA, it is important to consult with a qualified healthcare provider to determine if it is the right treatment option for you.

References:

  1. Shapiro SA, Kazmerchak SE, Heckman MG, Zubair AC, O’Connor MI. A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis. Am J Sports Med. 2017 Apr;45(5):82-90. doi: 10.1177/0363546516662455. Epub 2016 Nov 21. PMID: 27872109.
  2. Emadedin M, Aghdami N, Taghiyar L, Fazeli R, Moghadasali R, Jahangir S, Farjad R, Baghaban Eslaminejad M. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012 Jul;15(7):422-8. doi: 012157/AIM.007. PMID: 22724876.
  3. Kim YS, Kwon OR, Sunwoo MH, et al. Clinical results of bone marrow aspirate concentrate cell therapy in patients with knee osteoarthritis: a 1-year follow-up. J Pain Res. 2018;11:1345-1359. Published 2018 Jul 18. doi:10.2147/JPR.S164